In Memory of Adam Opiela-Sethi Lab's Gastrointestinal Cancer Research's Fundraising Page

Dedicated to Colorectal Cancer Research with the support of Dana-Farber and the Jimmy Fund
Dedicated to Colorectal Cancer Research with the support of Dana-Farber and the Jimmy Fund

WHY WE'RE FUNDRAISING WITH THE JIMMY FUND WALK TO FIGHT CANCER

 

 

Led by Joe Opiela, our team walks in memory of and dedication to Adam Opiela, who passed away from metastatic colon cancer on July 25th, 2021 at the all-too-young age of 30.  As part of an inpatient team, I took care of Adam in the beginning of June and then again in July.  He faced many challenges during his clinical course.  I was constantly impressed with his even demeanor, friendly attitude and kind interactions; we often talked about the NBA playoffs, exchanging notes and analyses.  Please see his obituary to learn more about Adam.  While taking care of Adam, I often felt helpless, and I certainly wish I could offer him more.  Because we believe we can do better for Adam and others, we are committed to basic science and translational colorectal cancer research, hoping to make breakthroughs that will impact lives in positive ways.

The overall goal of the Sethi lab is to combine clinical observations and evaluation of patient samples with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally dependent upon its power to generate a deeper understanding of human disease and ultimately improve patient care. We are particularly committed to defining the fundamental mechanisms underlying colorectal cancer with the hope that such insight will translate into new mechanisms to prevent and treat cancer.

Colorectal cancer remains the second leading cause of cancer-mortality worldwide and is responsible for an alarming increasing trend in incidence among younger individuals.   The intestine is a special organ in that it is the most rapidly renewing tissue in our body; the gut lining is replenished every 2 to 5 days.  Maintaining the intestinal lining therefore requires stem cells to constantly give rise to mature cells to perform their specialized function before dying.  Disruption of this natural maturation is a hallmark of colorectal cancer.  Our lab is focused on defining the molecular components that block proper maturation in cancer cells.  We also have designed a unique discovery platform to help us screen thousands of drugs to find the specific agents that overcome this block in maturation.  We strongly believe the next generation of therapeutics will restore proper maturation in colon cancer cells, reprogramming them to live out their natural life cycle.  We have also noticed that there are certain features that are conserved in the initiation of colorectal cancer.  We aim to study the genetic and molecular basis of hereditary and therapy-associated polyposis to bring new insight into this work.  Using innovative mouse models and patient-derived organoids, we hope to define the clinical and functional significance of these conserved events. 

In addition to our research efforts, we are dedicated to the mentorship of the next generation of physicians and scientists.  We believe in their potential to change the world. Please see our 2022 newsletter and visit the Sethi Lab Website for more details.

Thank you for supporting our team in the Jimmy Fund Walk. Together, we can defy cancer!

PROGRESS TO GOAL

Raised:$36,420
Goal:$50,000
25team members

THANK YOU TO OUR TEAM MEMBERS

C = Team Captain
NAME
AMOUNT RAISED
x223x
x$36,420.00x

THANK YOU TO OUR TEAM DONORS

NAME
AMOUNT
Team Honor Roll
Abby Hechtman
$100
Abhay Singh
$200
Alex in support of Nilay and team!
Allison and Kevin Stone
Amy Burbank
Andre Abouhala
$200
Angie Bodozian
Anonymous
Anonymous
Anonymous
Anonymous
Anonymous
$100
Anonymous
$100
Anonymous
$100
Anonymous
Anonymous
$50
Anonymous
Anonymous
Anonymous
Anonymous
Anonymous
Anonymous
Anonymous
$30
Anonymous
Barbara and John Spillane in loving memory of Adam.
Barbara Deal
$30
Bear and Liz Wojcik
$300
Betsy and Eddie Jacobs
Bill and Vicki
$500
Bob and Marietta Cooney
$100
Brett Garofalo
Bridget Fischer
$300
Bryan and Steph
Caitlin Jensen
$20
Carolyn Kemp & Eric Broege
$500
Cathy and John Sullivan
Cathy Ehrlich & Paul Mattie
$250
Chris Lakhiani
$100
Ciara Bartholomew
$50
Cody Armstrong
Colleen & Scott Hopkins
$50
Connor & Robyn Hatten
CTF
$100
Damon Calivas
Daniel J Gold
Daniel Palombo
$300
Danielle
$50
Daulet Aitymbayev
$40
Dave and Casey Schiemer
$200
David & Jeanne Hill
$150
David Landy and Katie Knox
Dean and Evangeline Calivas
$500
Debbie & Brian Doyle
$50
Dewey and Jamie Parsons
$100
Diane & Russ Hallisey
$200
Diego Cadavid, MD
$150
Dr Robert and Carol Norman
$180
Eben Ludlow
$50
Emily Sobiecki
$130
Eric Boole
Erica Price
Erin S
$30
Frank Schepps
George and Patty Cioto
$100
Gerry and Kim O'Loughlin
$100
Ginny Blanford and John Bryant
Grammy
$25
Greg Crane
Harrison Everts
Harry L. Bodozian
Heidi (Welch) Thompson
$30
Holly and Ryan LoRusso
$100
in memory of Adam Joseph Opiela
Jack and Yupapon McCanna
$100
Jake Kramer
James & Maria Wilcox
$300
Jamie Wells
Jane Hill and Andy Dempsey
$300
Jay + Maria
Jeannine Margolis
$50
jeff bogosian
$100
Jennifer P Carter
Jill Landy
$50
Joanne & Paul Morrissey
$100
Joanne Romanow and Thomas Fennell
$100
John & Laurie Andersen
$50
John and Cynthia Sobiecki
$100
John and Dorothy Owen
$100
John Barrett
John Sweeney
$100
Jonathan Reisman
Joseph and Franchesca Charney
$100
Joyce Fastino
$200
JP
$1,000
Karen & Tom Scotti
$50
Karen C Jessey
$100
Karen W
$50
Karina Erickson
Kathleen Cooney
$100
Kathy and Mike Stack
$250
Katrina Athanasiadis
Kelly & Joe Ewaskiw
$50
kenneth charney
$100
Kristen Fischer
Laura and Charlie
$300
Lauren & Brian Nadeau
$100
Lauren Lannan
Lauren Sanfilippo
Lauren Spera
Leslie Power
$50
Leslie Wardrop
$100
Lexi Farraye
$50
Linda & Brian Geraghty
Linda McCloud
Lisa Kimball and Warren olsen
$200
Lori Basilico
$100
Lorraine Charney
$50
Lyn Uhl and Garret White
$50
Madeline & Ryan Woodward
Marianne and Nick Tawa
$100
Marion and John Castellucci
$100
Marissa Gumas
$500
Mark O'D
$250
Mary and Brent Wheeldon
$100
Mary Noering
$30
Matt
Matt & Lee Boole
$100
Matthew Calivas
$300
Maura Jeanne Dasilva
$100
Maureen and Kevin Cooney
$50
Meaghan Champagne
Melissa Grella
Melville Seibolt
$100
Michael & Katherine
Michael Cooney
Michael Dolan
Michael Hynes & Family
$100
Mike Decina
$100
Miss Candace Flint
$50
Molly Masterson
Mr. Emily Sobiecki
$130
Mr. Giancarlo Bergonzi
$500
Mr. Jeff Suby
$100
Mr. Joe Opiela
$30
Mr. Joe Terry
$300
Mr. Joe Terry
Mr. Joginder kundra
$350
Mr. Matthew Charney
$50
Mr. Paul Borosavage
$30
Mr. Roth Wilkofsky
$100
Mrs. Cheryl dwyer
$100
Mrs. Ellen Strunk
$100
Mrs. Shana Sporman
$130
Mrs. Shweta Mahajan Sethi
$30
Ms. Elizabeth Leik
$20
Ms. Georgia Lobb
$100
Ms. Henrietta Movsessian
Ms. Jayne M Donegan
$530
Ms. Joyce Nilsen
$200
Ms. Kimberly Coutinho
$50
Ms. Leslie Shrager
$50
Ms. Lisa McAuliffe
$50
Ms. Paula Decubellis
$110
Ms. Susann Mark
$100
Nancy & Jack DONNELLY
Nancy Poon
$30
Nancy Schiemer
$100
Nick C.
Nick Kafker
Nicole Cisz
$100
Nicole Graham
$50
Nilay Sethi
$500
Olivia Sheerin
Olivia Tawa
$100
Onc G
$150
Pam and Michael Fishlow
$100
Patricia Posadowski
$300
Patty and Paul Graham in memory of Adam Opiela
$50
Paul & Tracey Hogan
$100
Paul A Smith
$100
Paul Doan
$40
Paul Margaret Russell Greene
$100
Pete Boylan
Peter and Jean Lynch
$150
Philip and Kathryn Boole
$200
Philip and Kathryn Boole
Pornlada Likasitwatanakul
$40
Pranshu Sahgal
$40
Pratyusha Bala
$40
Quinn Family
$250
Rachael Chase
Reed and Becca
$175
Reed Cammarota
$120
Reed Cammarota
$45
Richard DeSorgher
$100
Rob Mary Mintz
$205
Rob Quan
Robert B McDonald
$100
Robert B Tucker
$500
Robert Kalfus
$100
Ryan, Rachel & Avery Hogan
$100
Ryley Negrelli
$50
Sandi Kirshner and Bruce Hayes
Scott
$50
Scott and Christine Yerganian
$100
Scott Cook
$500
Sergey Rusak
$20
Sharon & Nate
Sheree Dolan
$250
Sherri & Richard Decina
$100
Stephen M. Hayes
$100
Steven Kramer
$50
Stonegate Group / Dean Calivas
$250
Stonegate Group Dean Calivas
$250
Susan & Peter Andrews
$50
Susan and Bill Haycock
$100
Sweet Sophie Scents
$50
The Adams Family
$150
The Bernard Family
$100
The Deady Family
$100
The Eamer Family
The O'Connor Fischer Family
The Ray Family
$200
The Whooley Family
$100
Tiff, Bryan, Silas, and Rylan say GOOOOOOO, BB!!! <3
TIM LANDRY
$100
Tom Conlon
$100
Trissa, Tim and Etta Bowen
Virginia Lanigan & Glenn Ticehurst
Walt &M
$100
Warren family
$150
YASHIKA PARASHAR
$40
Zhixin Li
$30
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Every dollar raised helps fuel Dana-Farber Cancer Institute's mission.
Together, we can defy cancer!














The 2022 Boston Marathon Jimmy Fund Walk

Dedicated to Colorectal Cancer Research with the support of Dana-Farber and the Jimmy Fund
Dedicated to Colorectal Cancer Research with the support of Dana-Farber and the Jimmy Fund

In Memory of Adam Opiela-Sethi Lab's Gastrointestinal Cancer Research

 

 

Led by Joe Opiela, our team walks in memory of and dedication to Adam Opiela, who passed away from metastatic colon cancer on July 25th, 2021 at the all-too-young age of 30.  As part of an inpatient team, I took care of Adam in the beginning of June and then again in July.  He faced many challenges during his clinical course.  I was constantly impressed with his even demeanor, friendly attitude and kind interactions; we often talked about the NBA playoffs, exchanging notes and analyses.  Please see his obituary to learn more about Adam.  While taking care of Adam, I often felt helpless, and I certainly wish I could offer him more.  Because we believe we can do better for Adam and others, we are committed to basic science and translational colorectal cancer research, hoping to make breakthroughs that will impact lives in positive ways.

The overall goal of the Sethi lab is to combine clinical observations and evaluation of patient samples with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally dependent upon its power to generate a deeper understanding of human disease and ultimately improve patient care. We are particularly committed to defining the fundamental mechanisms underlying colorectal cancer with the hope that such insight will translate into new mechanisms to prevent and treat cancer.

Colorectal cancer remains the second leading cause of cancer-mortality worldwide and is responsible for an alarming increasing trend in incidence among younger individuals.   The intestine is a special organ in that it is the most rapidly renewing tissue in our body; the gut lining is replenished every 2 to 5 days.  Maintaining the intestinal lining therefore requires stem cells to constantly give rise to mature cells to perform their specialized function before dying.  Disruption of this natural maturation is a hallmark of colorectal cancer.  Our lab is focused on defining the molecular components that block proper maturation in cancer cells.  We also have designed a unique discovery platform to help us screen thousands of drugs to find the specific agents that overcome this block in maturation.  We strongly believe the next generation of therapeutics will restore proper maturation in colon cancer cells, reprogramming them to live out their natural life cycle.  We have also noticed that there are certain features that are conserved in the initiation of colorectal cancer.  We aim to study the genetic and molecular basis of hereditary and therapy-associated polyposis to bring new insight into this work.  Using innovative mouse models and patient-derived organoids, we hope to define the clinical and functional significance of these conserved events. 

In addition to our research efforts, we are dedicated to the mentorship of the next generation of physicians and scientists.  We believe in their potential to change the world. Please see our 2022 newsletter and visit the Sethi Lab Website for more details.

Thank you for supporting our team in the Jimmy Fund Walk. Together, we can defy cancer!

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