Sethi Lab: Gastrointestinal Cancer Research's Fundraising Page

2020 jimmy fund walk team!
2020 jimmy fund walk team!

WHY WE'RE FUNDRAISING WITH THE JIMMY FUND WALK TO FIGHT CANCER

This year, we are walking in dedication to Adam Opiela, who passed away from metastatic colon cancer on July 25th, 2021 at the all-too-young age of 30.  As part of an inpatient team, I took care of Adam in the beginning of June and then again in July.  He faced many challenges during his clinical course.  I was constantly impressed with his even demeanor, friendly attitude and kind interactions; we often talked about the NBA playoffs, exchanging notes and analyses.  Please see his obituary to learn more about Adam.  While taking care of Adam, I often felt helpless, and I certainly wish I could offer him more.  Because we believe we can do better for Adam and others, we are committed to basic science and translational colorectal cancer research, hoping to make breakthroughs that will impact lives in positive ways.

The overall goal of the Sethi lab is to combine clinical observations and evaluation of patient samples with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally dependent upon its power to generate a deeper understanding of human disease and ultimately improve patient care. We are particularly committed to defining the fundamental mechanisms underlying colorectal cancer with the hope that such insight will translate into new mechanisms to prevent and treat cancer.

Colorectal cancer remains the second leading cause of cancer-mortality worldwide and is responsible for an alarming increasing trend in incidence among younger individuals.   The intestine is a special organ in that it is the most rapidly renewing tissue in our body; the gut lining is replenished every 2 to 5 days.  Maintaining the intestinal lining therefore requires stem cells to constantly give rise to mature cells to perform their specialized function before dying.  Disruption of this natural maturation is a hallmark of colorectal cancer.  Our lab is focused on defining the molecular components that block proper maturation in cancer cells.  We also have designed a unique discovery platform to help us screen thousands of drugs to find the specific agents that overcome this block in maturation.  We strongly believe the next generation of therapeutics will restore proper maturation in colon cancer cells, reprogramming them to live out their natural life cycle.  We have also noticed that there are certain features that are conserved in the initiation of colorectal cancer.  We aim to study the genetic and molecular basis of hereditary and therapy-associated polyposis to bring new insight into this work.  Using innovative mouse models and patient-derived organoids, we hope to define the clinical and functional significance of these conserved events. 

In addition to our research efforts, we are dedicated to the mentorship of the next generation of physicians and scientists.  We believe in their potential to change the world. Please visit the Sethi Lab Website for more details.

PROGRESS TO GOAL

Raised:$21,615.60
Goal:$21,001
14team members

THANK YOU TO OUR TEAM MEMBERS

C = Team Captain
NAME
AMOUNT RAISED
x37x
x$21,615.60x

THANK YOU TO OUR TEAM DONORS

NAME
AMOUNT
Team Honor Roll
Abhay Singh
$55
Alex Flores in memory of Adam
$100
Ali Bock
$100
Alison McDermott
$100
Allegra Sacco
$100
Ann/Michael & Carolyn/Celia in memory of Adam Opiela
Anonymous
Anonymous
Anonymous
$101
Anonymous
Anonymous
Anqi Dong
$100
Austin friends and colleagues in honor of Adam Opiela
Barbara Calzolari
$100
Betsy and Eddie Jacobs
Brenna Griffin
$100
Brianna Roberts
$100
Brie Williams
$100
Brooslin Family
$200
C Mess
$40
Calivas Family in memory of Adam Opiela
$500
Carolyn Kemp & Eric Broege in memory of Adam Opiela
$1,000
Cathy and John Sullivan
Cathy Callaghan
Cathy Ehrlich & Paul Mttie
$500
Chris and Becky Ray and Family
$200
Colleen and Scott Hopkins
$50
Dave and Jeanne Hill
$200
Davis House Girls, Bates 2018
$140
Diego Cadavid and family
$200
Dr. Nilay Sethi
$55
Drew McCarthy
$150
Eileen and Scott Bianchi in memory of Adam Opiela
$50
Emily Sobiecki
$105
Emily Theurer
$100
Frances & Stephen Sacco
Giridhar Family
$100
Greg Crane
$100
Heather Atwood and David Rabin
$100
Holly and Ryan LoRusso
$100
in memory of Adam J. Opiela
in memory of Adam J. Opiela
James Sears
$100
Jane and Paul Harrity in memory of Adam Opiela
Jay, Matt and Eric
Jennifer Largaespada
Jennifer P Carter
$300
Jill Landy
$50
Joanne & Tom Fennell
Joe Gobiel
$50
John and Cynthia Sobiecki
$100
John Opiela in Memory of Adam Opiela
$100
Jonathan Reisman
$100
Joseph and Carolyn LoRusso
Julia Pion
$100
Kaitlyn Rubin and family in memory of Adam Opiela
$200
Kanwal Singh Matharu
$101
Karen & Tom Scotti in memory of Adam Opiela
Kelly Ryan
$250
Kristen Fischer and Peter Durnan in honor of Adam Opiela
Kristi Mannis
$100
Laura Coyne & Charlie Freeman
$1,000
Lauren & Brian Nadeau
$100
Leo
$100
Lexi Korwin
$100
Lincoln Smith
$500
Lisa Kimball and Warren Olsen
$200
Lubo & Abby Svetiev
$100
Margaret and Tom Nowak
$300
Mark and Susan Thompson
$500
Martin Dunn
$100
Mary & Brent Wheeldon
$100
Mary Ellen & Frank Zappulla in memory of Adam Opiela
$500
matthew Bartolini
$300
MEDFIELD FOOTBALL
Melissa Grella
$250
Michael Joseph
$20
Mr. Brian Strunk
$105
Mr. Charles Champagne
$100
Mr. joginder Kundra
$100
Mr. Richard Toni
$500
Mr. Whitaker Whitehouse
$100
Mr. Whitaker Whitehouse
$5
Mrs. Pervesh Sethi
$1,000
Mrs. Shana Sporman
$105
Mrs. Shweta Mahajan Sethi
$30
Ms. Elizabeth J. O'Connor
Ms. Jayne M Donegan
$1,005
Ms. Laurie Pippitt
$5
Ms. Mary M. Kemp
$100
Nathan Samras
$100
Negrelli Family
$50
Neighborhood Friends in Memory of Adam
$500
Nicholas Vara
$50
Olivia Tawa
$100
Patricia Ann and George Cioto
$50
Patti and George Whooley in memory of Adam
$100
Paul, Tracey & Ben Hogan
$100
Peter and Jean Lynch
$100
Phil & Kathy Boole
Polly and Bill Walker
Rob Quan
$150
Robert Lazar
$100
Roth Wilkofsky, in Memory of Adam Opiela
$250
Sarah & Noel
$200
Sherri & Rick Decina
$100
State Street for Brenna Griffin
$100
State Street for Brianna Roberts
$100
State Street for Julia Pion
$100
State Street for Melissa Grella
$250
State Street for Robert Quan
$150
State Street for Trysia Odorczuk
$100
Tara DiPersio & Family
$50
Tawa Family
$100
The Arone Family in honor of Adam Opiela
$500
The Eamer Family
$200
The Geraghty Family
$200
The Miller Family in memory of Adam Opiela
The Ruzzo Family
$50
The Stone Family In memory of Adam Opiela
$100
Tracy Tasi
$75
Trish, Gary, and Brian Foster
Trysia Odorczuk
$100
Virginia Lanigan & Glenn Ticehurst, in memory of Adam Opiela
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Every dollar raised helps fuel Dana-Farber Cancer Institute's 50-50 balance between lifesaving research and total patient care.
Together, we can conquer cancer!














2021 Boston Marathon Jimmy Fund Walk

2020 jimmy fund walk team!
2020 jimmy fund walk team!

Sethi Lab: Gastrointestinal Cancer Research

This year, we are walking in dedication to Adam Opiela, who passed away from metastatic colon cancer on July 25th, 2021 at the all-too-young age of 30.  As part of an inpatient team, I took care of Adam in the beginning of June and then again in July.  He faced many challenges during his clinical course.  I was constantly impressed with his even demeanor, friendly attitude and kind interactions; we often talked about the NBA playoffs, exchanging notes and analyses.  Please see his obituary to learn more about Adam.  While taking care of Adam, I often felt helpless, and I certainly wish I could offer him more.  Because we believe we can do better for Adam and others, we are committed to basic science and translational colorectal cancer research, hoping to make breakthroughs that will impact lives in positive ways.

The overall goal of the Sethi lab is to combine clinical observations and evaluation of patient samples with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally dependent upon its power to generate a deeper understanding of human disease and ultimately improve patient care. We are particularly committed to defining the fundamental mechanisms underlying colorectal cancer with the hope that such insight will translate into new mechanisms to prevent and treat cancer.

Colorectal cancer remains the second leading cause of cancer-mortality worldwide and is responsible for an alarming increasing trend in incidence among younger individuals.   The intestine is a special organ in that it is the most rapidly renewing tissue in our body; the gut lining is replenished every 2 to 5 days.  Maintaining the intestinal lining therefore requires stem cells to constantly give rise to mature cells to perform their specialized function before dying.  Disruption of this natural maturation is a hallmark of colorectal cancer.  Our lab is focused on defining the molecular components that block proper maturation in cancer cells.  We also have designed a unique discovery platform to help us screen thousands of drugs to find the specific agents that overcome this block in maturation.  We strongly believe the next generation of therapeutics will restore proper maturation in colon cancer cells, reprogramming them to live out their natural life cycle.  We have also noticed that there are certain features that are conserved in the initiation of colorectal cancer.  We aim to study the genetic and molecular basis of hereditary and therapy-associated polyposis to bring new insight into this work.  Using innovative mouse models and patient-derived organoids, we hope to define the clinical and functional significance of these conserved events. 

In addition to our research efforts, we are dedicated to the mentorship of the next generation of physicians and scientists.  We believe in their potential to change the world. Please visit the Sethi Lab Website for more details.

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